Tire Size Difference/Effect for 50/50 Dual Sport

[Beast250]

Hello All!

Thanks for taking the time to read/assist. Ive read some info out there that typically the larger the wheel, the better the bite in dirt.

im curious thoughts on the difference in wheel sizes for someone intending to ride 50/50 street/off road.

Specifically, would there be a drastic difference between these two:
17"- both- front(110/70-17)/back(130/70-17)
vs
21" front (80/100-21) / 18" back (110/100-18)

Im researching the major differences between the DB-36 and the Hawk 250.

thanks again!